Bus travels, Tour and transport

Geography

Dalian is located west of the Yellow Sea (Korea Bay) and east of Bohai Sea. With a coastline of 1,906 km, it governs the southernmost Liaodong Peninsula and about 260 surrounding islands and reefs.

History

Part of the State of Yan in the Spring and Autumn Period, Dalian became a small town in the 1880s, when the Qing Empire established bridges, cannon platforms and camps there. Named after the Dalianwan Bay (大连? of the Yellow Sea northeast of the peninsula, it was officially called Dalian in 1899, and the term was first used in October 1879 by Li Hongzhang in a document.

Dalian of south Pulandian was occupied by the British in 1858, returned to the Chinese in the 1880s, and then occupied by Japan in 1895 during the first Sino-Japanese War. From 1898-1905, it was occupied by the Russians and renamed Dalny (Qingniwaqiao 青泥洼桥 of Zhongshan District, Dalian) and Port Arthur (Lvshunkou). After the Russo-Japanese war Port Arthur was conceded to Japan (Treaty of Portsmouth), who set up the Kwantung Leased Territory or Guandongzhou. Since the foundation of Manchukuo in 1932, the sovereignty of the territory moved from China to Manchukuo. Japan still leased it from Manchukuo. In 1937, the modern Dalian City was enlarged and modernized by the Japanese as two cities: the northern Dairen (Dalian) and the southern Ryojun (Lushun).

After World War II, Dalian was not returned to China, but taken over by Soviets with theoretical Chinese overlordship (see Yalta Conference), and was returned to full Chinese control in 1955, although the first communist Chinese mayor of the new Lvda Administrative Office was elected in 1945. The name Lvda was formed from the initial letters of Lvshunkou and Dalian. Because of the sudden closure of many Japanese businesses, many Dalian residents were out of work for a while.

On December 1, 1950, Lvda was made into a city again. From March 12, 1953 to August 1, 1954, it became a municipality of China|municipality. The city's name was changed from Lvda to Dalian on March 5, 1981, after the State Council approved it on February 9. It was upgraded from a prefecture-level city to a sub-provincial city in 1994, with no change in its administrative subdivisions.

A common treatment for herpes can delay the need for HIV drugs in people with both infections, say US researchers.

A study of 3,300 patients in Africa found aciclovir reduced the risk of HIV progression by 16%, The Lancet reports.

Although a "modest" effect, the researchers said the cheap treatment was a simple way of keeping people with HIV healthy for longer.

One expert said it was important to note that aciclovir did not seem to make HIV patients less infectious.

The researchers from the University of Washington, Seattle, concentrated on people infected with HIV-1 - the most common type of infection.

It is known that most people who are infected with HIV-1 are also infected with herpes simplex virus type 2 (HSV2), or genital herpes.

Previous studies have shown that keeping the herpes virus suppressed reduces HIV levels but it was unclear whether this would slow down the disease.

Those in the trial were either given a twice daily dose of aciclovir or a dummy pill and then they were monitored for two years.

At the end of the study, 284 people on aciclovir had either started taking HIV medication, had a drop in CD4 count suggesting they should be on medication or had died. The comparable figure for patients taking the placebo was 324.

Use of aciclovir treatment did not reduce HIV transmission to their heterosexual partners.

More options

The researchers pointed out that HIV treatment with antiretroviral drugs would probably have a greater effect on reducing HIV disease progression than was seen with aciclovir.

But the herpes treatment may provide an additional option for individuals who have not reached medical thresholds for initiating antiretroviral therapy.

"Further investigation is needed to establish if suppression of this herpes virus has a role in HIV-1 treatment for people not eligible for antiretroviral therapy."

Study leader, Dr Jairam Lingappa, said: "While the HIV disease ameliorating effect we have observed is modest, it could add one more tool to help people with HIV infection stay healthy for longer."

Gus Cairns, editor of HIV Treatment Update, said: "It's nice to see a positive result in this field.

"There are biological reasons to believe that treating people's herpes could make them less likely to acquire HIV, or less likely to transmit it if they already have it, but results of trials testing the idea have been disappointing.

"Now at least we find that aciclovir, a very cheap, non-toxic and widely-available drug, can prolong the time some patients may be able to stay off the more expensive, and sometimes toxic, HIV drugs."

He added that the delay in HIV progression seen in the study may translate into a year or two off HIV medications.

"The only reservation I have is that aciclovir doesn't appear to make people less infectious, whereas the HIV drugs certainly do."

Drinking beer especially pale ale strengthens your bones and could stop them becoming brittle, a study suggests.

Researchers found that the drink contained a substance that boosts bones and could mean they are less likely to suffer from osteoporosis.

They discovered that beer, especially pale ales, contains high levels of silicon known to slow down the bone thinning that leads to fractures and boosting the formation of new bone.

The finding, published in the Journal of the Science of Food and Agriculture, backs up previous research which also showed that the drink was good at fending off brittle bones – especially in women.

"The factors in brewing that influence silicon levels in beer have not been extensively studied", said Dr Charles Bamforth, lead author at the University of California.

They found that lighter beers with a greater use of hops had the most silicon.

Silicon is present in beer in the soluble form of orthosilicic acid (OSA), up to half of which can be absorbed by the body making beer a major contributor to silicon intake in the Western diet.

Based on these findings, some studies suggest moderate beer consumption may help fight osteoporosis, a disease of the skeletal system characterised by low bone mass and deterioration of bone tissue.

The researchers found that the extra heat used in malting darker beers tended to destroy some of the silicon. Beers with more hops naturally had more silicon they found.

Osteoporosis or low bone density is often described as a silent epidemic of the 21st century. In the UK alone it results in more than 200,000 fractures annually and costs the NHS more than £1 billion a year.

Three million Britons are affected by osteoporosis.

The actual biological role of silicon in bone health and formation is not known though it is thought to help manufacture collagen, one of its major components.

"Beers containing high levels of malted barley and hops are richest in silicon," concludes Dr. Bamforth.

Beer, especially pale ales, contains high levels of silicon known to slow down the bone thinning that leads to fractures Photo: CORBIS

"Wheat contains less silicon than barley because it is the husk of the barley that is rich in this element. While most of the silicon remains in the husk during brewing, significant quantities of silicon nonetheless are extracted into wort and much of this survives into beer."

Dr Claire Bowring, National Osteoporosis Society, said the research did not mean that people head for the pub.

“These findings mirror results from previous studies which concluded that moderate alcohol consumption could be beneficial to bones," she said.

However, while the National Osteoporosis Society welcomes measures to improve bone health we do not recommend anyone increases their alcohol consumption on the basis of these studies. While low quantities of alcohol may appear to have bone density benefits, higher intakes have been show to decrease bone strength, with an alcohol intake of more than two units per day actually increasing the risk of breaking a bone.

"There are also many other health concerns linked with alcohol which cannot be ignored.”

Scientists have succeeded in growing a crystal that reveals the structure of the enzyme, integrase, and this could improve the design of the integrase inhibiting drugs commonly used for AIDS treatment.

Integrase – an enzyme found in retroviruses like HIV – plays a key role in HIV infection.

“When HIV infects someone, it uses integrase to paste a copy of its genetic information into their DNA,” the researchers from Imperial College in London stated.

“Availability of the integrase structure means that researchers can begin to fully understand how existing drugs that inhibit integrase are working, how they might be improved, and how to stop HIV developing resistance to them.”

Many researchers had tried and failed for more than 20 years “to work out the three-dimensional structure of integrase bound to viral DNA”, prior to this study, they stated.

To grow a crystal of “sufficient quality to allow determination of the three-dimensional structure”, the scientists from Imperial College in London and Harvard University in Boston conducted more than 40 000 trials.

These results in seven kinds of crystals, only one of which was of high enough quality for their study.

Lead author Dr Peter Cherepanov said: “We went back to square one and started by looking for a better model of HIV integrase, which could be more amenable for crystallization.

“Despite initially painstakingly slow progress and very many failed attempts, we did not give up and our effort was finally rewarded.”

Their findings are published this week in the journal Nature.